Head to Head
| Uruguay Clausura | 2023/11/11 19:30 | Nacional De Football v Penarol | D | 2-2 |
| Uruguay Apertura | 2023/04/01 19:00 | Penarol v Nacional De Football | L | 2-0 |
| Club Friendly List | 2023/01/23 23:30 | Nacional De Football v Penarol | L | 5-6 |
| Uruguay Clausura | 2022/09/04 18:30 | Nacional De Football v Penarol | W | 3-1 |
| Uruguay Apertura | 2022/02/27 20:00 | Penarol v Nacional De Football | L | 1-0 |
| Club Friendly List | 2022/01/26 22:00 | Penarol v Nacional De Football | L | 1-0 |
| Uruguay Clausura | 2021/10/31 19:00 | Penarol v Nacional De Football | D | 0-0 |
| Copa Sudamericana | 2021/07/23 00:30 | Penarol v Nacional De Football | W | 0-1 |
| Copa Sudamericana | 2021/07/16 00:30 | Nacional De Football v Penarol | L | 1-2 |
| Uruguay Apertura | 2021/07/04 19:00 | Nacional De Football v Penarol | W | 2-0 |
| Uruguay Clausura | 2021/02/03 21:30 | Penarol v Nacional De Football | D | 0-0 |
| Uruguay Torneo Intermedio | 2020/12/13 20:30 | Penarol v Nacional De Football | L | 3-2 |
| Uruguay Apertura | 2020/08/09 18:00 | Nacional De Football v Penarol | D | 1-1 |
| Uruguay Grand Final | 2019/12/15 20:00 | Nacional De Football v Penarol | W | 1-0 |
| Uruguay Grand Final | 2019/12/11 23:30 | Penarol v Nacional De Football | W | 0-2 |
| Uruguay Clausura | 2019/11/17 19:00 | Nacional De Football v Penarol | D | 0-0 |
| Uruguay Torneo Intermedio | 2019/09/01 18:00 | Nacional De Football v Penarol | W | 3-0 |
| World Club Friendlies | 2019/07/06 21:15 | Penarol v Nacional De Football | L | 2-1 |
| Uruguay Apertura | 2019/05/12 18:00 | Penarol v Nacional De Football | D | 1-1 |
| Uruguay Supercopa | 2019/02/03 23:15 | Nacional De Football v Penarol | W | 5-4 |
| World Club Friendlies | 2019/01/22 01:15 | Penarol v Nacional De Football | L | 2-0 |
| Uruguay Grand Final | 2018/11/11 19:30 | Nacional De Football v Penarol | L | 1-2 |
| Uruguay Clausura | 2018/10/20 18:00 | Nacional De Football v Penarol | D | 1-1 |
| Uruguay Apertura | 2018/04/22 19:00 | Penarol v Nacional De Football | D | 1-1 |
| World Club Friendlies | 2018/01/27 00:00 | Nacional De Football v Penarol | L | 1-3 |
| World Club Friendlies | 2018/01/23 00:30 | Penarol v Nacional De Football | L | 2-0 |
| Uruguay Clausura | 2017/09/17 19:00 | Nacional De Football v Penarol | L | 0-2 |
| World Club Friendlies | 2017/08/14 23:30 | Nacional De Football v Penarol | W | 1-0 |
| Uruguay Apertura | 2017/04/05 23:30 | Penarol v Nacional De Football | D | 1-1 |
| Uruguay Apertura | 2016/11/27 20:00 | Penarol v Nacional De Football | W | 0-3 |