Penarol 4-1 Cerro Largo 2021-04-14 00:30
Stadium: Estadio Campeon del Siglo Round: 14
Referee: Andres Ismael Cunha Soca Home Manager: Mauricio Larriera Away Manager: Luis Danielo Nunez Maciel
Head to Head
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Penarol | D | 2-2 |
| Uruguay Clausura | 2021/02/17 22:30 | Cerro Largo v Penarol | D | 1-1 |
| Uruguay Apertura | 2020/08/27 23:15 | Penarol v Cerro Largo | W | 2-0 |
| Uruguay Clausura | 2019/12/05 23:30 | Penarol v Cerro Largo | W | 2-1 |
| Uruguay Apertura | 2019/06/02 19:00 | Cerro Largo v Penarol | L | 1-0 |