[4] Guayaquil City 3-2 Mushuc Runa [12] 2020-11-14 18:00
Stadium: Estadio Christian Benitez Betancourt Round: 22
Referee: Augusto Bergelio Aragon Bautista Home Manager: Pool Gavilanez Away Manager: Ricardo Dillon
Head to Head
| Ecuador LigaPro Serie A | 2020/09/26 19:45 | Mushuc Runa v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2019/08/25 19:45 | Guayaquil City v Mushuc Runa | W | 4-2 |
| Ecuador LigaPro Serie A | 2019/04/06 20:00 | Mushuc Runa v Guayaquil City | L | 3-2 |
| Ecuador LigaPro Serie A | 2016/10/30 17:00 | Mushuc Runa v Guayaquil City | W | 0-2 |
| Ecuador LigaPro Serie A | 2016/09/10 21:00 | Guayaquil City v Mushuc Runa | D | 0-0 |
| Ecuador LigaPro Serie A | 2016/07/24 19:00 | Mushuc Runa v Guayaquil City | W | 0-1 |
| Ecuador LigaPro Serie A | 2016/02/06 00:00 | Guayaquil City v Mushuc Runa | W | 3-1 |
| Ecuador LigaPro Serie A | 2015/10/18 17:00 | Mushuc Runa v Guayaquil City | D | 1-1 |
| Ecuador LigaPro Serie A | 2015/09/05 21:30 | Guayaquil City v Mushuc Runa | D | 2-2 |
| Ecuador LigaPro Serie A | 2015/05/17 17:00 | Mushuc Runa v Guayaquil City | L | 1-0 |
| Ecuador LigaPro Serie A | 2015/02/28 21:00 | Guayaquil City v Mushuc Runa | W | 2-0 |