Stadium: Benedetti–Wehrli Stadium Round: 8
| NCAAF | 2022/11/19 18:00 | North Central Illinois v Lake Forest Foresters | W | 50-0 |
| NCAAF | 2022/11/12 19:00 | North Central Illinois v Augustana Augie | W | 63-3 |
| NCAAF | 2022/11/05 18:00 | Illinois Wesleyan Titans v North Central Illinois | W | 3-68 |
| NCAAF | 2022/10/29 18:00 | North Central Illinois v North Park Vikings | W | 59-0 |
| NCAAF | 2022/10/22 18:00 | Washington Bears v North Central Illinois | W | 0-31 |
| NCAAF | 2022/10/15 18:00 | North Central Illinois v Millikin Big Blue | W | 65-0 |
| NCAAF | 2022/10/08 18:00 | Carroll Pioneers v North Central Illinois | W | 0-73 |
| NCAAF | 2022/10/01 23:00 | North Central Illinois v Wheaton Thunder | W | 33-20 |
| NCAAF | 2022/11/19 17:00 | Carnegie Mellon Tartans v Depauw Tigers | W | 45-14 |
| NCAAF | 2022/11/12 19:00 | Case Western Reserve Spartans v Carnegie Mellon Tartans | W | 7-20 |
| NCAAF | 2022/10/29 17:00 | Carnegie Mellon Tartans v St Vincent Bearcats | W | 30-12 |
| NCAAF | 2022/10/22 23:00 | Carnegie Mellon Tartans v Geneva Golden Tornadoes | W | 41-0 |
| NCAAF | 2022/10/15 17:00 | Washington And Jefferson Presidents v Carnegie Mellon Tartans | W | 7-12 |
| NCAAF | 2022/10/08 17:00 | Waynesburg Yellow Jackets v Carnegie Mellon Tartans | W | 20-27 |
| NCAAF | 2022/10/01 23:00 | Carnegie Mellon Tartans v Westminster Titans | W | 10-0 |
| NCAAF | 2022/09/24 19:00 | Thiel Tomcats v Carnegie Mellon Tartans | W | 6-35 |