Stadium: UPMC Cooper Fieldhouse
Home Manager: Keith Dambrot Away Manager: Erik Martin
| NCAAB | 2022/11/12 17:00 | South Carolina State v Tennessee State | L | 61-80 |
| NCAAB | 2022/11/09 00:00 | South Carolina State v SC Gamecocks | L | 77-80 |
| NCAAB | 2022/03/10 23:00 | South Carolina State v Morgan State | L | 77-80 |
| NCAAB | 2022/03/04 00:30 | South Carolina State v North Carolina Central | L | 62-67 |
| NCAAB | 2022/03/01 00:30 | South Carolina State v Howard | L | 62-72 |
| NCAAB | 2022/02/26 23:00 | South Carolina State v Norfolk State | L | 59-63 |
| NCAAB | 2022/02/22 00:30 | Delaware State v South Carolina State | W | 74-79 |
| NCAAB | 2022/02/19 21:00 | Maryland Eastern-Shore v South Carolina State | W | 63-70 |
| NCAAB | 2022/11/12 00:00 | Duquesne v Kentucky | L | 52-77 |
| NCAAB | 2022/11/09 00:00 | Montana v Duquesne | W | 63-91 |
| NCAAB | 2022/03/09 20:30 | Duquesne v Rhode Island | L | 77-79 |
| NCAAB | 2022/03/05 19:00 | La Salle v Duquesne | L | 85-76 |
| NCAAB | 2022/03/03 00:00 | Duquesne v George Washington | L | 93-98 |
| NCAAB | 2022/02/26 17:30 | Duquesne v Rhode Island | L | 54-70 |
| NCAAB | 2022/02/24 00:00 | Davidson v Duquesne | L | 74-50 |
| NCAAB | 2022/02/19 23:00 | Duquesne v St. Bonaventure | L | 55-81 |