[1] River Plate 4-0 Colo Colo [2] 2022-05-20 00:00
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 5
Referee: Andres Matonte Home Manager: Marcelo Gallardo Away Manager: Gustavo Quinteros
Head to Head
| Copa Libertadores | 2022/04/28 00:00 | Colo Colo v River Plate | W | 1-2 |
Home History
| Argentina Liga Profesional | 2022/05/12 00:30 | River Plate v CA Tigre | L | 1-2 |
| Argentina Liga Profesional | 2022/05/09 00:00 | River Plate v Platense | W | 2-1 |
| Copa Libertadores | 2022/05/05 22:00 | Fortaleza EC v River Plate | D | 1-1 |
| Argentina Liga Profesional | 2022/05/01 00:30 | Sarmiento v River Plate | W | 0-7 |
| Copa Libertadores | 2022/04/28 00:00 | Colo Colo v River Plate | W | 1-2 |
| Argentina Liga Profesional | 2022/04/24 22:00 | River Plate v Atlético Tucumán | D | 1-1 |
| Argentina Liga Profesional | 2022/04/20 22:00 | CA Talleres de Córdoba v River Plate | L | 1-0 |
| Argentina Liga Profesional | 2022/04/18 00:30 | Banfield v River Plate | W | 1-2 |
Away History
| Chile Primera Division | 2022/05/14 22:00 | Colo Colo v Coquimbo Unido | W | 4-0 |
| Chile Primera Division | 2022/05/09 22:00 | Curico Unido v Colo Colo | W | 1-2 |
| Copa Libertadores | 2022/05/06 02:00 | Alianza Lima v Colo Colo | D | 1-1 |
| Copa Libertadores | 2022/04/28 00:00 | Colo Colo v River Plate | L | 1-2 |
| Chile Primera Division | 2022/04/24 16:30 | Universidad Catolica v Colo Colo | D | 1-1 |
| Chile Primera Division | 2022/04/17 22:00 | Colo Colo v Cobresal | W | 2-1 |
| Copa Libertadores | 2022/04/13 22:00 | Colo Colo v Alianza Lima | W | 2-1 |
| Chile Primera Division | 2022/04/10 21:30 | Union Espanola v Colo Colo | L | 2-1 |