Head to Head
| Chile Primera Division | 2022/02/13 21:00 | La Serena v Colo Colo | D | 1-1 |
| Chile Primera Division | 2021/10/20 17:00 | La Serena v Colo Colo | W | 1-4 |
| Chile Cup | 2021/07/05 00:00 | Colo Colo v La Serena | W | 4-0 |
| Chile Cup | 2021/07/01 19:30 | La Serena v Colo Colo | W | 1-3 |
| Chile Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | W | 2-0 |
| Chile Primera Division | 2020/12/08 21:30 | Colo Colo v La Serena | L | 0-2 |
| Chile Primera Division | 2020/03/07 15:00 | La Serena v Colo Colo | W | 1-2 |
| Chile Cup | 2017/08/03 00:00 | Colo Colo v La Serena | W | 4-0 |
Home History
| Copa Sudamericana | 2022/07/06 00:30 | Internacional v Colo Colo | L | 4-1 |
| Chile Primera Division | 2022/07/01 22:00 | Everton de Vina v Colo Colo | D | 1-1 |
| Copa Sudamericana | 2022/06/29 00:30 | Colo Colo v Internacional | W | 2-0 |
| Chile Cup | 2022/06/23 22:00 | Deportes Temuco v Colo Colo | W | 1-5 |
| Chile Cup | 2022/06/18 22:00 | Colo Colo v Deportes Temuco | D | 0-0 |
| Chile Primera Division | 2022/05/30 22:00 | Colo Colo v Nublense | D | 0-0 |
| Copa Libertadores | 2022/05/25 22:00 | Colo Colo v Fortaleza EC | L | 3-4 |
| Chile Primera Division | 2022/05/22 19:00 | O'Higgins v Colo Colo | D | 1-1 |
Away History
| Chile Primera Division | 2022/07/03 19:00 | La Serena v O'Higgins | W | 1-0 |
| Chile Cup | 2022/06/25 16:30 | La Serena v Universidad de Concepcion | L | 1-2 |
| Chile Cup | 2022/06/18 21:30 | Universidad de Concepcion v La Serena | L | 4-3 |
| Chile Primera Division | 2022/05/28 19:00 | La Serena v Audax Italiano | W | 3-2 |
| Chile Primera Division | 2022/05/22 00:00 | Union La Calera v La Serena | D | 1-1 |
| Chile Primera Division | 2022/05/14 16:30 | La Serena v Palestino | D | 0-0 |
| Chile Primera Division | 2022/05/07 21:30 | Universidad de Chile v La Serena | L | 2-0 |
| Chile Primera Division | 2022/04/23 19:00 | La Serena v Curico Unido | L | 1-3 |