[15] Santos Laguna 1-1 Leon [12] 2022-04-25 00:00
Weather: Good Stadium: Estadio TSM Corona Pitch: Good Round: 16
Referee: Adonai Escobedo Gonzalez Home Manager: Eduardo Fentanes Away Manager: Ariel Holan
Head to Head
| Mexico Liga MX | 2021/08/22 00:00 | Leon v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |
| Mexico Liga MX | 2020/11/03 03:00 | Leon v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2020/01/20 00:45 | Santos Laguna v Leon | W | 3-2 |
| Mexico Liga MX | 2019/08/29 00:00 | Leon v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/03/03 01:00 | Leon v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2018/09/16 21:00 | Santos Laguna v Leon | W | 3-0 |
| Mexico Liga MX | 2018/02/15 01:00 | Santos Laguna v Leon | W | 5-1 |
Home History
| Mexico Liga MX | 2022/04/20 02:00 | Mazatlan FC v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/04/17 00:00 | Santos Laguna v Queretaro | D | 1-1 |
| Mexico Liga MX | 2022/04/10 00:06 | Monterrey v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/04/04 00:00 | Santos Laguna v Pachuca | W | 3-1 |
| Mexico Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| Mexico Liga MX | 2022/03/06 03:00 | Chivas Guadalajara v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/03/03 03:00 | Santos Laguna v Unam Pumas | W | 3-2 |
Away History
| Mexico Liga MX | 2022/04/21 02:00 | Club America v Leon | L | 2-0 |
| Mexico Liga MX | 2022/04/16 22:00 | Leon v Puebla | L | 0-1 |
| Mexico Liga MX | 2022/04/09 22:00 | Atletico San Luis v Leon | L | 2-0 |
| Mexico Liga MX | 2022/04/03 22:00 | Leon v Queretaro | D | 1-1 |
| Mexico Liga MX | 2022/03/21 03:00 | Mazatlan FC v Leon | W | 1-2 |
| CONCACAF Champions Cup | 2022/03/18 00:30 | Leon v Seattle Sounders | D | 1-1 |
| Mexico Liga MX | 2022/03/12 23:00 | Leon v Tigres UANL | L | 0-3 |
| CONCACAF Champions Cup | 2022/03/09 03:00 | Seattle Sounders v Leon | L | 3-0 |