| Uruguay Reserve League | 2021/10/26 13:00 | Torque Reserves v Atletico River Plate Reserves | L | 2-1 |
| Uruguay Reserve League | 2021/10/18 18:30 | Atletico River Plate Reserves v Penarol Reserves | L | 0-5 |
| Uruguay Reserve League | 2021/10/04 18:30 | Rentistas Reserves v Atletico River Plate Reserves | D | 2-2 |
| Uruguay Reserve League | 2021/09/28 13:00 | Atletico River Plate Reserves v Montevideo Wanderers Reserves | L | 3-4 |
| Uruguay Reserve League | 2021/09/06 18:00 | Boston River Reserves v Atletico River Plate Reserves | W | 1-2 |
| Uruguay Reserve League | 2021/08/31 18:00 | Atletico River Plate Reserves v Atletico Fenix Reserves | L | 0-2 |
| Uruguay Reserve League | 2021/08/23 14:00 | Plaza Colonia Reserves v Atletico River Plate Reserves | W | 1-3 |
| Uruguay Reserve League | 2021/08/17 13:00 | Atletico River Plate Reserves v Sud America Reserves | W | 3-0 |
| Uruguay Reserve League | 2021/10/25 18:30 | Villa Espanola Reserves v Liverpool Montevideo Reserves | D | 0-0 |
| Uruguay Reserve League | 2021/10/19 18:30 | Cerrito Reserves v Villa Espanola Reserves | L | 2-1 |
| Uruguay Reserve League | 2021/10/04 18:30 | Villa Espanola Reserves v Nacional de Montevideo Reserves | L | 1-7 |
| Uruguay Reserve League | 2021/09/28 18:00 | Deportivo Maldonado Reserves v Villa Espanola Reserves | L | 4-2 |
| Uruguay Reserve League | 2021/09/07 18:00 | Torque Reserves v Villa Espanola Reserves | L | 2-0 |
| Uruguay Reserve League | 2021/08/23 16:00 | Rentistas Reserves v Villa Espanola Reserves | L | 3-2 |
| Uruguay Reserve League | 2021/08/03 18:00 | Boston River Reserves v Villa Espanola Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/07/27 15:00 | Villa Espanola Reserves v Atletico Fenix Reserves | L | 1-3 |