Head to Head
| England National League North | 2020/12/12 15:00 | Guiseley v Southport | W | 4-2 |
| England National League North | 2019/08/10 14:00 | Southport v Guiseley | L | 3-0 |
| England National League North | 2019/03/02 15:00 | Guiseley v Southport | L | 0-1 |
| England National League North | 2019/01/08 19:45 | Southport v Guiseley | L | 1-0 |
| England National League | 2017/04/01 14:00 | Southport v Guiseley | W | 0-1 |
| England National League | 2016/10/08 14:00 | Guiseley v Southport | W | 2-1 |
| England National League | 2016/03/26 15:00 | Southport v Guiseley | L | 2-0 |
| England National League | 2015/09/22 18:45 | Guiseley v Southport | D | 1-1 |
Home History
| England National League North | 2021/12/04 15:00 | Guiseley v York | L | 0-1 |
| England FA Trophy | 2021/12/01 19:45 | Ashton Utd v Guiseley | W | 1-2 |
| England National League North | 2021/11/23 19:45 | Chester v Guiseley | W | 0-1 |
| England National League North | 2021/11/20 15:00 | Blyth Spartans v Guiseley | L | 1-0 |
| England National League North | 2021/11/13 15:00 | Guiseley v Hereford FC | L | 0-2 |
| England FA Cup | 2021/11/06 15:00 | AFC Wimbledon v Guiseley | L | 1-0 |
| England National League North | 2021/10/30 14:00 | Darlington 1883 v Guiseley | L | 5-1 |
| England National League North | 2021/10/23 14:00 | Guiseley v Chorley | D | 0-0 |
Away History
| England National League North | 2021/12/04 15:00 | Southport v Hereford FC | W | 2-0 |
| England FA Trophy | 2021/11/30 19:45 | Southport v Darlington 1883 | W | 6-5 |
| England National League North | 2021/11/23 19:45 | Southport v Alfreton Town | W | 2-0 |
| England National League North | 2021/11/20 15:00 | Leamington v Southport | D | 1-1 |
| England National League North | 2021/11/13 15:00 | Southport v Boston Utd | W | 4-1 |
| England National League North | 2021/11/02 19:45 | Southport v Chorley | D | 0-0 |
| England National League North | 2021/10/30 14:00 | Southport v Chester | W | 3-2 |
| England National League North | 2021/10/26 18:45 | Southport v Darlington 1883 | W | 3-0 |