[20] Michigan State 38-21 Northwestern [20] 2021-09-04 01:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2019/09/21 16:00 | Michigan State v Northwestern | W | 31-10 |
| NCAAF | 2018/10/06 16:00 | Northwestern v Michigan State | L | 29-19 |
| NCAAF | 2017/10/28 19:30 | Michigan State v Northwestern | L | 31-39 |
| NCAAF | 2016/10/15 19:30 | Northwestern v Michigan State | L | 54-40 |
| NCAAF | 2012/11/17 12:00 | Michigan State v Northwestern | L | 20-23 |
| NCAAF | 2011/11/26 12:00 | Northwestern v Michigan State | W | 17-31 |
| NCAAF | 2010/10/23 12:00 | Northwestern v Michigan State | W | 27-35 |
Home History
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | L | 7-49 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2020/10/24 16:00 | Rutgers v Michigan State | L | 38-27 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | W | 27-21 |
Away History
| NCAAF | 2021/01/01 18:00 | Auburn v Northwestern | W | 19-35 |
| NCAAF | 2020/12/19 17:00 | Northwestern v Ohio State | L | 10-22 |
| NCAAF | 2020/12/12 17:00 | Illinois v Northwestern | W | 10-28 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | L | 20-29 |
| NCAAF | 2020/11/21 20:30 | Wisconsin v Northwestern | W | 7-17 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | W | 27-20 |
| NCAAF | 2020/11/07 17:00 | Nebraska v Northwestern | W | 13-21 |
| NCAAF | 2020/10/31 19:30 | Northwestern v Iowa | W | 21-20 |